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Kupffer cells KCs , the resident macrophages in the liver, play pivotal roles in the progression and resolution of liver fibrosis[ 16 ]. Macrophage heterogeneity in liver injury and fibrosis. To explore this hypothesis, we analyzed the expression and distribution of KCs and HMGB1 in fibrotic liver by immunofluorescent staining. Liver fibrosis protects mice from acute hepatocellular injury. On the other hand, liver fibrosis represents the wound healing response to liver injury due to a variety of etiologies[ 6 , 7 ]. The statistical methods used in this study were reviewed by Dr. The filtrate was centrifuged and washed. Peer-review report classification.

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